Endocrine Abstracts

Background: Cushing’s syndrome is the most common cause of endogenous hypercortisolism that results from the excessive exposure to glucocorticoids. Even though this syndrome is represented by a constellation of clinical signs and symptoms, the most common next features are the truncal obesity and the moon facies, making it hard not to be recognized. It is more common in women (F/M=5-8:1) with an avarage age of 20–40 years.Case Presentation: A 3...

Objective: The aim of this study was to determine the frequencies of vitamin D receptor (VDR) Bsm1, Fok1, ApaI, TaqI and estrogen receptor α (ESR1) PvuII and XbaI polymorphisms in Romanian patients and to investigate their involvement in postmenopausal osteoporosis.Methods: The study was carried out on 82 postmenopausal women, aged over 60, divided into two groups: group 1-postmenopausal women with osteoporosis (34 subjects), group 2-postmenopausal ...

Introduction: Clear cell renal carcinoma (ccRCC) is a subtype of renal cell carcinoma, the most frequent one (80%) and usually affecting only one kidney. It is twice as common in men than women between 50 to 70 years old. It can be associated with some genetic conditions that predispose patients to ccRCC, like Von Hipple-Lindau disease. Some clinical observations and molecular studies raised the hypothesis that RCC is a hormone−dependent tumor.Case...

Background: Papillary thyroid cancer (PTC) incidence has increased substantially over the last decades. Although 4% of thyroid cancers may induce a sarcoid reaction in the thyroid gland, sarcoidosis (SA) as a disease may exist with PTC, although causality remais uncertain and their coexistence is rarely reported in the literature. They occurs in both genres, between 30–40 years, but females are more predisposed.Case presentation: A 65-year-old man, ...

Introduction: Central diabetes insipidus is a rare disorder, characterized by a failure of the posterior pituitary to produce vasopressin that lead to hypotonic polyuria and polydipsia. Diabetes insipidus may be due to post-pituitary surgery, where sometimes the posterior lobe also has to be removed or damaged; other injury as fractures of the skull, trauma, infiltrative lesions, tumors/metastases, idiopathic or rare genetic causes. As the sensation of thirst is the key homeos...

Multiple endocrine neoplasya type 2 (MEN-2) is a rare hereditary complex disorder caused by a germline activating mutation of the RET proto-oncogene. The estimated prevalence is approximately 1:30.000. Three clinical forms have been described depending on the phenotype: MEN2A (80%), MEN2B and familial medullary thyroid carcinoma (MTC).Clinically, MEN2A present with MTC (80–100%), unilateral or bilateral pheocromocytoma (40%) and primary hyperparath...

Studies evaluated bone involvement in the metabolic control of fat cells. It has been reported that osteocalcin acts as a hormone in the body, causing beta cells in the pancreas to release more insulin, and at the same time directing fat cells to release adiponectin, which increases sensitivity to insulin.The aim: Of the study was to evaluate osteocalcin levels in subjects with metabolic syndrome compared with age and sex matched control groups.<p cl...

Objectives: Metabolic syndrome, especially obesity and diabetes are associated and responsible for a depressive psychological status. Meanwhile, antidepressors are responsible for metabolic disturbances, such as insulin resistance. The study aims to determine predictive factors of response to antidepressant pharmacotherapy in patients with metabolic syndrome.Materials and methods: A retrospective study conducted in Institute Parhon’s Department for ...

Objective: CT findings indicating that a patient is at risk for developing optic neuropathy are worth- while observations.Aim: The aim of our study was to determine the utility of CT imaging in identifying patients at risk for optic neuropathy and to compare quantifiable nonvolumetric CT data from a large series of orbits with Graves ophthalmopathy.Method: A total of 226 patients (452 orbits), 175 women (350 orbits) and 51 men (102...

To examine the hormonal characteristics related to age of reproductive axis, serum hormone profiles and inhibins A and B were investigated in fertile and menopausal women.Subjects: Forty-three cycling women (23–40-year-old) and 75 menopausal women (55–70-year-old) were studied. Serum 17-OHP, DHEA, DHEAS, androstendion, estradiol, estrone, progesterone, testosterone, free testosterone, DHT, SHBG, inhibin A and inhibin B, LH, FSH, Prl, TSH, GH, I...